Histological antiphospholipid associated nephropathy versus lupus nephritis in patients with systemic lupus erythematosus –an observational cross-sectional study with longitudinal follow up (Arthritis Research & Therapy)

IntroductionRenal involvement is a severe complication in Systemic Lupus Erythematosus (SLE). Moreover, a subset of SLE patients develop the anti-phospholipid syndrome (APS), characterised by the occurrence of anti-phospholipid antibodies (aPL) in combination with macro- and microvascular thrombotic manifestations, including acute and chronic antiphospholipid associated nephropathy (APLN). Clinical presentations of lupus nephritis and APLN are similar and a renal biopsy is necessary to differ between the conditions. Our aim with this study was to investigate the occurrence of histopathological findings consistent with APLN (hAPLN) in renal biopsies from SLE patients and to investigate associations with aPL specificities, clinical manifestations, HLA-DRB1 alleles and long term renal outcome.MethodConsecutive renal biopsies from 112 SLE patients with renal involvement were investigated and evaluated for findings of hAPLN, in all 236 renal biopsies. Data from biopsy reports and clinical information were collected. Autoantibodies against cardiolipin (aCL) and β2glykoprotein1 (β2GP1) were measured by enzyme-linked immunosorbent assay (ELISA). Lupus anticoagulant (LA) test was determined with a modified Dilute Russel Viper Venom method. HLA genotyping was performed by sequence-specific primer-polymerase chain reaction. Renal outcome was determined at study end. Results: The prevalence of hAPLN was 14.3 % among SLE patients with renal involvement. Compared to patients with pure lupus nephritis (LN), occurrence of hAPLN was associated with intima changes (OR = 24, CI:3.0-189.8, p