Effect-site concentration of propofol required for LMA-Supreme™ insertion with and without remifentanil: a randomized controlled trial (BMC Anesthesiology)

Background: A new supraglottic device, the LMA-Supreme™, has recently become available for clinical use. Information on anaesthetic and co-adjuvant requirements for insertion of the LMA-Supreme™ is limited. The present study aimed to evaluate the optimal effect-site concentration of propofol in 50 % (EC 50 ) of adults necessary for successful insertion of the LMA-Supreme™ and to examine remifentanil’s effect on propofol requirements. Methods: Fifty-eight elective patients (aged 18–60 years; ASA (American Society Anaesthesiologists) physical status classification I and II) scheduled for day surgery were randomly assigned to one of two groups: propofol with saline or propofol with remifentanil. Anaesthesia was induced by target-controlled infusion according to predetermined effect-site concentrations of propofol and remifentanil (5 ng.mL −1 ). The EC 50 was calculated using Dixon’s up-and-down method. Ten minutes following drug administration, LMA-Supreme™ insertion was attempted without the use of muscle relaxant drugs. Results: In the propofol + saline group, the EC 50 of propofol required for LMA-Supreme™ insertion was 6.32 ± 0.67 μg.mL −1 (95 % CI, 5.69–6.94 μg.mL −1 ). With the addition of remifentanil at an effect-site concentration of 5 ng.mL −1 , the EC 50 of propofol required for LMA-Supreme™ insertion was 2.50 ± 0.80 μg.mL −1 (95 % CI, 1.82–3.17 μg.mL −1 ; p