NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation (Current Biology)

Gallini et al. identify NuMA phosphorylation as the determinant for the Aurora-A spindle orientation function. In metaphase, Aurora-A governs the distribution of NuMA between poles and cortex by phosphorylating Ser1969NuMA, which controls NuMA mobility at poles. A novel microtubule-binding domain of NuMA is identified compatible with LGN binding.