Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage (Immunity)

Aire-dependent promiscuous gene expression in the thymus is critical for the protection of peripheral organs from autoimmune attack. Savage and colleagues demonstrate that in Aire-/- mice, Treg cell-biased clones are mis-directed into the T conventional cell subset and dominate the T cell infiltrate in autoimmune target lesions.