Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells (Immunity)

Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs), but specific pathways that allow LLPC persistence are unknown. Bhattacharya and colleagues show that LLPCs import and use glucose for antibody glycosylation, but in times of metabolic stress, they divert glucose to generate pyruvate for survival.