Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 Dendritic Cells (Immunity)

Priming of tissue-resident memory T cells (Trm) is not well characterized. Iborra et al. find that prolonged antigen crosspresentation in combination with specific signals from DNGR-1+ dendritic cells are required for optimal Trm priming but not for their differentiation, and are dispensable for the generation of circulating memory T cells.