Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance (Cell Reports)

Lee et al. show that, contrary to expectations, the loss of hepatic fatty acid oxidation (FAO) confers resistance to weight gain and adiposity in response to a high-fat diet. Additionally, they show that loss of hepatic FAO--and, consequently, hepatic gluconeogenesis--protects mice from high-fat-diet-induced glucose intolerance.