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RSS FeedsIJERPH, Vol. 14, Pages 1059: Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain (International Journal of Environmental Research and Public Health)

 
 

13 september 2017 15:40:52

 
IJERPH, Vol. 14, Pages 1059: Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain (International Journal of Environmental Research and Public Health)
 




Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m2, respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood-brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.


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41 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 14, Pages 1058: Community Capacity Building for Physical Activity Promotion among Older Adults--A Literature Review (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 14, Pages 1061: Comment on: Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring. Int. J. Environ. Res. Public Health 2017, 14, 27 (International Journal of Environmental Research and Public Health)
 
 
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