The Role of N-?-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting (Molecular Cell)

Lee et al. reveal an unexpected function for Naa10p, which is primarily known to acetylate nascent peptides from ribosomes, in maintaining global DNA methylation and marking the imprinted allele for genomic imprinting maintenance. Their results suggest that defects in DNA methylation and genomic imprinting may contribute to Naa10p-associated Ogden syndrome.