Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells (Molecular Cell)

Jin et al. demonstrate that IFN-induced Tetherin recruits MARCH8 to mediate the K27-linked ubiquitination of MAVS for NDP52-dependent autophagic degradation, serving as a suppressor to prevent the sustained activation of RLR-mediated type I IFN signaling via a negative feedback loop.