Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine (Cell Host & Microbe)

The in vivo tropism of norovirus, a gastrointestinal pathogen, is unknown. Lee et al. discover that a small number of intestinal epithelial cells are a reservoir for persistent murine norovirus. This tropism is regulated by viral protein NS1 and host IFN-lambda, findings that provide critical insight into norovirus pathogenesis.