Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling (Cell Metabolism)

Dysfunctional mitochondrial dynamics are a hallmark of aging, but the physiological consequences are unknown. Weir et al. show that mitochondrial network remodeling is required for AMPK- and dietary restriction-mediated longevity, and identify a downstream role for fatty acid oxidation and peroxisome function in C. elegans.