The Glycolytic Pyruvate Kinase Is Recruited Directly into the Viral Replicase Complex to Generate ATP for RNA Synthesis (Cell Host & Microbe)

RNA viruses co-opt several host proteins to aid their replication in infected cells. Chuang et al. demonstrate that a small plant virus recruits the cellular glycolytic pyruvate kinase (PK) directly into the viral replicase complex. PK supplies ATP to fuel co-opted cellular helicases, which drives rapid viral RNA synthesis.