Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance (Developmental Cell)

Ando et al. identify osteoblast progenitor cells (OPCs) in zebrafish and find that OPCs are derived from embryonic somites and are reserved in niches of bone-forming tissues while being replenished from mesenchymal precursors. OPCs migrate from the niches and generate osteoblasts during bone regeneration and maintenance in adult zebrafish.