The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules (Molecular Cell)

Transcriptome analysis coupled with single-molecule FISH validation of stress granule cores provides new insight into the mRNAs and ncRNAs that accumulate in stress granules. Ten percent of bulk mRNA molecules accumulate in stress granules, and targeting efficiency correlates with poorer translation efficiency and longer coding and UTR length.