Targeting Interleukin-1? Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor ? Signaling (Immunity)

TGF-? signaling has an unquestionable but still controversial role in the pathogenesis of aortic aneurysm. Da Ros et al. demonstrate that disruption of TGF-? signaling in SMCs activates an autocrine IL-1? pathway that acts as a danger signal to recruit innate immune cells in the adventitia through CCL2.