Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing (Cell Host & Microbe)

Paharik, Parlet, et al. demonstrate that the human commensal Staphylococcus caprae competes with Staphylococcus aureus by inhibiting quorum sensing. Through signal interference, S. caprae reduces methicillin-resistant S. aureus burden in both skin colonization and infection, highlighting the benefits of healthy skin flora and suggesting a new avenue for probiotic therapy.