Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23 (Structure)

Liu et al. present the crystal structure of a non-human EGFR kinase, C. elegans LET-23. Their findings offer insights into the regulation of ancestral EGFRs, demonstrating that LET-23 is activated allosterically by oligomerization, similarly to human EGFR, but through a mechanism that is likely structurally distinct.