Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria (Developmental Cell)

Kruppa et al. demonstrate that MYO6 forms a complex with Parkin and is recruited to damaged, ubiquitinated mitochondria. MYO6 promotes F-actin cage assembly to isolate and prevent refusion of dysfunctional organelles. Loss of MYO6 leads to a mitophagy defect with an accumulation of mitophagosomes and downstream mitochondrial dysfunction.