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RSS FeedsDicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects (Cell Host & Microbe)

 
 

6 march 2018 13:30:04

 
Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects (Cell Host & Microbe)
 


Poirier et al. show that during RNA virus infection of insects, circular viral DNA is produced, regulated by Dicer-2 helicase domain. The main template for viral DNA is defective viral genomes, which appear to be key viral products modulating the host immune response and the establishment of viral persistence.


 
211 viewsCategory: Cell Biology, Immunology, Microbiology
 
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