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RSS FeedsMolecules, Vol. 23, Pages 859: 1-(Acylamino)alkylphosphonic Acids--Alkaline Deacylation (Molecules)

 
 

9 april 2018 18:00:49

 
Molecules, Vol. 23, Pages 859: 1-(Acylamino)alkylphosphonic Acids--Alkaline Deacylation (Molecules)
 




The alkaline deacylation of a representative series of 1-(acylamino)alkylphosphonic acids [(AC)-AAP: (AC) = Ac, TFA, Bz; AAP = GlyP, AlaP, ValP, PglP and PheP] in an aqueous solution of KOH (2M) was investigated. The results suggested a two-stage reaction mechanism with a quick interaction of the hydroxyl ion on the carbonyl function of the amide R-C(O)-N(H)- group in the first stage, which leads to instant formation of the intermediary acyl-hydroxyl adducts of R-C(O-)2-N(H)-, visible in the 31P NMR spectra. In the second stage, these intermediates decompose slowly by splitting of the RC(O-)2-N(H)- function with the subsequent formation of 1-aminoalkylphosphonate and carboxylate ions.


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89 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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