CnoX Is a Chaperedoxin: A Holdase that Protects Its Substrates from Irreversible Oxidation (Molecular Cell)

Bleach is a powerful oxidant that kills bacteria by causing protein aggregation. Goemans et al. identified Escherichia coli CnoX (YbbN) as a bleach-activated chaperone that uniquely combines holdase activity with the ability to protect its substrates from irreversible oxidation. After bleach stress, CnoX transfers its client proteins to GroEL/ES and DnaK/J/GrpE.