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RSS FeedsDevelopmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons (Current Biology)

 
 

21 may 2018 12:00:36

 
Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons (Current Biology)
 


Mire et al. discover a unique interaction between Ephrin-B1 and Nrp1 that turns off the axonal response to the Sema3C attractant. This molecular on/off switch allows callosal axons to move across mirror-symmetrical gradients of Sema3C on both sides of the brain midline.


 
85 viewsCategory: Biology
 
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