Strong G-Protein-Mediated Inhibition of Sodium Channels (Cell Reports)

Mattheisen et al. demonstrate a G-protein-dependent pathway that strongly inhibits voltage-gated sodium channel currents in the vast majority of cortical neurons. The mechanism involves profound slowing of recovery from inactivation. The strong and widespread effects on voltage-gated sodium channels position this signaling pathway to have substantial influence on neuronal excitability.