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RSS FeedsHemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells (Immunity)

 
 

31 may 2018 00:00:13

 
Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells (Immunity)
 




Gentek et al. demonstrate that Cdh5-CreERT2 can be used to selectively fate map yolk sac and definitive hematopoiesis. Temporally defined Cdh5-CreERT2 lineage tracing reveals that mast cells are yolk sac derived in the embryo but replaced by definitive hematopoiesis in the adult, a feature they share with macrophages.


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58 viewsCategory: Immunology
 
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