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RSS FeedsA Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer (Cell Metabolism)

 
 

1 june 2018 06:00:07

 
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer (Cell Metabolism)
 


Cancer patients with metabolic and sleep dysfunction have worse prognoses. Using a mouse model of breast cancer, Borniger, Walker II, et al. provide evidence that tumors deregulate satiety hormones, which likely alters the activity of hypocretin/orexin neurons. Aberrant activity in these cells impairs sleep and alters glucose metabolism via the sympathetic nervous system.


 
184 viewsCategory: Cell Biology
 
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