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RSS FeedsIJERPH, Vol. 15, Pages 1103: Association between Serum 25-Hydroxy Vitamin D Levels and the Prevalence of Adult-Onset Asthma (International Journal of Environmental Research and Public Health)

 
 

7 june 2018 00:00:42

 
IJERPH, Vol. 15, Pages 1103: Association between Serum 25-Hydroxy Vitamin D Levels and the Prevalence of Adult-Onset Asthma (International Journal of Environmental Research and Public Health)
 




The major circulating metabolite of vitamin D (25(OH)D) has been implicated in the pathogenesis for atopic dermatitis, asthma and other allergic diseases due to downstream immunomodulatory effects. However, a consistent association between 25(OH)D and asthma during adulthood has yet to be found in observational studies. We aimed to test the association between 25(OH)D and asthma during adulthood and hypothesised that this association would be stronger in non-atopic participants. Using information collected on the participants of the 1958 birth cohort, we developed a novel measure of atopic status using total and specific IgE values and reported history of eczema and allergic rhinitis. We designed a nested case-control analysis, stratified by atopic status, and using logistic regression models investigated the association between 25(OH)D measured at age 46 years with the prevalence of asthma and wheezy bronchitis at age 50 years, excluding participants who reported ever having asthma or wheezy bronchitis before the age of 42. In the fully adjusted models, a 10 nmol/L increase in serum 25(OH)D prevalence had a significant association with asthma (aOR 0.94; 95% CI 0.88–1.00). There was some evidence of an atopic dependent trend in the association between 25(OH)D levels and asthma. Further analytical work on the operationalisation of atopy status would prove useful to uncover whether there is a role for 25(OH)D and other risk factors for asthma.


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96 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 15, Pages 1104: Involving Patients and Families in the Analysis of Suicides, Suicide Attempts, and Other Sentinel Events in Mental Healthcare: A Qualitative Study in The Netherlands (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 15, Pages 1102: Particulate Matter and Gaseous Pollutions in Three Metropolises along the Chinese Yangtze River: Situation and Implications (International Journal of Environmental Research and Public Health)
 
 
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