SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress (Molecular Cell)

Szoradi et al. uncover SHRED, a stress response pathway that hinges on the previously uncharacterized regulatory protein Roq1. Proteolytically cleaved Roq1 binds to the N-end rule ubiquitin ligase Ubr1 as a pseudosubstrate and directs Ubr1 toward misfolded proteins, thereby promoting the degradation of aberrant proteins.