mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation (Molecular Cell)

He et al. report that Foxk1 phosphorylation is inhibited by mTORC1 through suppression of GSK3 signaling, resulting in diminished Foxk1 14-3-3 binding. The hypophosphorylated Foxk1 accumulates in the nucleus, and it promotes mTORC1-mediated metabolic reprogramming through direct Foxk1-dependent and Foxk1/Hif1?-dependent gene expression.