Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function (Structure)

Chavent et al. investigate interactions of the EphA2 receptor tyrosine kinase with a membrane. Phosphatidylinositol phosphates (PIPs) mediate interaction of the kinase domain with the membrane, while kinase and juxtamembrane domains induce formation of nanoclusters of PIP molecules. These results enable computational reconstitution of a near complete EphA2 receptor model.