Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1 (Cell Reports)

Synaptic homeostasis is crucial for maintaining proper neuronal excitability and excitatory/inhibitory balance in the brain. Mao et al. report that an activity-dependent chromatin reader protein is required for homeostatic control of synaptic strength through the regulation of downstream target gene Ctnnb1.