Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to ?-Synuclein Gain (Cell Metabolism)

Lin et al. show that loss of the fly homolog of the neurodegeneration gene PLA2G6 (PARK14) impairs retromer function, causes ceramide accumulation, and leads to lysosomal dysfunction, which causes neuronal dysfunction. Their further data suggest that the uncovered retromer/ceramide/lysosome pathway may be common in Parkinson disease.