Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein (Cell Chemical Biology)

Countermeasures against dengue, Zika, and other flaviviruses are a large, unmet medical need. de Wispelaere et al. validate a conserved pocket of the flavivirus envelope protein as a target for small-molecule antivirals with broad-spectrum activity against flaviviruses.