Oncology
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28 september 2018 03:01:45 |
| HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis (Cancer Cell) |
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Tweet Sun et al. show that HOXA9 overexpression in myeloid and B progenitor cells induces emergence of leukemia-specific enhancers by recruiting CEBP? and the MLL3/MLL4 complex, leading to activation of an ectopic embryonic gene program. Genetic deletion of MLL3/MLL4 inhibits HOXA9/MEIS1-mediated leukemogenesis. |
| 100 viewsCategory: Cell Biology, Oncology |
 Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling (Cancer Cell)Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells (Cancer Cell) 
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