Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination (Cell Reports)

Timely and efficient transcription termination is essential for release of functional mRNAs as well as for Pol II recycling. Kecman et al. demonstrate that the conserved PP1 phosphatase Dis2 regulates transcription termination in fission yeast by mediating elongation to termination factor exchange and by dephosphorylating Pol II C-terminal domain.