CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming (Cell Stem Cell)

Liu and colleagues developed a high-throughput CRISPR activation screening approach to systematically identify transcription factors that efficiently promote neuronal fate from ESCs. Some of these single and pairwise factors can further reprogram fibroblasts into neurons, showing that this approach may have broad utility for engineering cell lineages.