Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory (Current Biology)

Swift et al. show that overactivity of the locus coeruleus, the main source of norepinephrine to the forebrain, during sleep interferes with signatures of NREM sleep and REM sleep associated with sleep-dependent memory consolidation. Maladaptive LC activity can impair next day hippocampal spatial encoding, producing long-term behavioral deficits.