ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier (Developmental Cell)

Glomerular podocytes maintain the kidney filtration barrier. Schell et al. show that the Arp2/3 machinery is required for podocyte process formation and adaptation to filtration barrier mechanical requirements via reciprocal interplay with the actomyosin network. Dendritic actin network loss results in actomyosin cytoskeleton activation and decreased adhesion, leading to podocyte detachment.