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RSS FeedsIJMS, Vol. 19, Pages 3922: Drosophila as a Model to Study Brain Innate Immunity in Health and Disease (International Journal of Molecular Sciences)

 
 

8 december 2018 18:00:15

 
IJMS, Vol. 19, Pages 3922: Drosophila as a Model to Study Brain Innate Immunity in Health and Disease (International Journal of Molecular Sciences)
 




Innate immunity is the first line of defense against invading pathogens and plays an essential role in defending the brain against infection, injury, and disease. It is currently well recognized that central nervous system (CNS) infections can result in long-lasting neurological sequelae and that innate immune and inflammatory reactions are highly implicated in the pathogenesis of neurodegeneration. Due to the conservation of the mechanisms that govern neural development and innate immune activation from flies to mammals, the lack of a classical adaptive immune system and the availability of numerous genetic and genomic tools, the fruit fly Drosophila melanogaster presents opportunities to investigate the cellular and molecular mechanisms associated with immune function in brain tissue and how they relate to infection, injury and neurodegenerative diseases. Here, we present an overview of currently identified innate immune mechanisms specific to the adult Drosophila brain.


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9 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 19, Pages 3923: Matrix Metalloproteinase Response of Dendritic Cell, Gingival Epithelial Keratinocyte, and T-Cell Transwell Co-Cultures Treated with Porphyromonas gingivalis Hemagglutinin-B (International Journal of Molecular Sciences)
IJMS, Vol. 19, Pages 3921: LeNRT1.1 Improves Nitrate Uptake in Grafted Tomato Plants under High Nitrogen Demand (International Journal of Molecular Sciences)
 
 
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