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RSS FeedsMolecules, Vol. 23, Pages 3232: Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives (Molecules)

 
 

8 december 2018 19:00:24

 
Molecules, Vol. 23, Pages 3232: Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives (Molecules)
 




The natural product phloroglucinol-based derivatives representing monoacyl-, diacyl-, dimeric acyl-, alkylated monoacyl-, and the nitrogen-containing alkylated monoacylphloro- glucinols were synthesized and evaluated for inhibitory activities against the inflammatory mediators such as inducible nitric oxide synthase (iNOS) and nuclear factor kappaB (NF-κB). The diacylphloroglucinol compound 2 and the alkylated acylphloroglucinol compound 4 inhibited iNOS with IC50 values of 19.0 and 19.5 µM, respectively, and NF-κB with IC50 values of 34.0 and 37.5 µM, respectively. These compounds may serve as leads for the synthesis of more potent anti-inflammatory compounds for future drug discovery.


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12 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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