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RSS FeedsMolecules, Vol. 23, Pages 3205: Function and Interactions of ERCC1-XPF in DNA Damage Response (Molecules)

 
 

8 december 2018 19:00:24

 
Molecules, Vol. 23, Pages 3205: Function and Interactions of ERCC1-XPF in DNA Damage Response (Molecules)
 




Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.


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36 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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