Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain (Structure)

Lee et al. assess the druggability of the ionotropic glutamate receptor subfamilies, using molecular dynamics simulations in the presence of drug-like molecules and X-ray crystallography. The study presents a ligand-binding site in the GluA3 N-terminal domain and supports the role of conformational plasticity in modulating ligand binding.