Cross-Chemistry Leads to Product Diversity from Atromentin Synthetases in Aspergilli from Section Nigri (Cell Chemical Biology)

Geib et al. investigated core structure formation by thioesterase domains of fungal NRPS-like enzymes. Exchange of thioesterase domains alters product formation, but requires close phylogenetic relationship of donor and acceptor. Product formation further depends on expression hosts with furanic acid rather than quinone core formation in aspergilli from section Nigri.