p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors (Cancer Cell)

Karras et al. report that high p62 expression in melanoma correlates with a high risk of metastasis. Independent of its role in autophagy, p62 recruits a subset of RNA-binding proteins in partnership with IGF2BP1 to extend the half-life of mRNAs of several pro-metastatic factors selectively in melanoma cells.