Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development (Current Biology)

Olstad et al. show that the cerebrospinal fluid flow dynamics in vivo are controlled by ciliary beating, heartbeat pulsations, and bodily movements. Together, these components balance the compartmentalization and the dispersion of CSF across the brain ventricles. Genetic disruption of ciliary beating leads to ventricular defects during development.