Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT (Immunity)

Dendritic cells can be divided into multiple functional subsets. Chopin et al. show that the transcription factor PU.1 promotes development of conventional dendritic cells while suppressing plasmacytoid dendritic cell formation. PU.1 functions by activating the expression of DC-SCRIPT, a key regulator of conventional dendritic cell differentiation.