Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation (Developmental Cell)

Mechanisms of tumor-induced host wasting are largely unknown. Song et al. provide evidence that tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation. They demonstrate that yki3SA-gut tumors produce vn and Pvf1 ligands to trigger MEK-associated tumor growth and host wasting, respectively.