Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation (Structure)

The interaction between UHRF1 and LIG1K126me3 is essential for DNA methylation maintenance. Kori et al. determined the crystal structure of the UHRF1 TTD bound to a LIG1K126me3 peptide, revealing the basis for the high TTD-binding affinity of LIG1K126me3, regulation by phosphorylation, and that LIG1K126me3 binding switches the overall structure of UHRF1.