Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay (Cell Reports)

Disulfide formation in the mitochondrial intermembrane space (IMS) is an essential process that is coupled to protein import. Here, Habich et al. report on a redox quality control step in which the import competence of substrates is tested, and when it fails, substrates are released to the cytosol for degradation.