ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition (Cell Metabolism)

Although metabolic reprogramming plays an important role in supporting tumor growth, little is known about the metabolic alterations that promote cancer metastasis. Lu et al. identify the supportive role of acyl-CoA thioesterase 12 (ACOT12), which regulates cellular acetyl-CoA levels and histone acetylation in promoting epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.